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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

在动画电影行业执迷于翻拍让观众有共鸣的老故事时,皮克斯却总能尝试新事物,把观众带到从未踏足的新领域。《寻梦环游记》由《玩具总动员3》导演李?昂克里奇执导,该片的视觉效果基于墨西哥的亡灵节。故事讲述了一个名叫米格尔的小男孩崇拜传奇吉他手欧内斯托?德?拉?克鲁兹,想学习如何能弹奏得和他一样好。于是他就像奥德赛一样踏上了改造性的自我发现之旅,进入死亡之地寻找那位已去世多年的偶像,还受到了一些关于创造力本质的教导。《寻梦环游记》是否能达到皮克斯2015年杰作《头脑特工队》的高度尚未可知,但这部电影绝对是一场视觉盛宴。该片将于11月15日在法国上映,11月22日在美国、克罗地亚和菲律宾上映,11月30日在以色列上映。(资料来源:迪士尼/皮克斯)
6. Cutting Down on Saturated Fats Could Preserve Your Memory

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

根据花旗居屋(Citi Habitats)提供的数据,在布鲁克林拟于明年投放市场的6527套新出租屋中,有1442套分布在贝德福德-斯图文森(Bedford-Stuyvesant)、布什维克(Bushwick)和克林顿山(Clinton Hill)。就在不久前,这些社区都还被视为不热门的地区。
好莱坞的明星们早已着手准备了数周,尤其是对于去当地南瓜地挑选一些南瓜这样的事来说。

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

From the themed collection: 陶瓷原料涨价的原因分析
Open Access Perspective

Soft matter science and the COVID-19 pandemic

单词fare 联想记忆:

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

其实我一直都在等你提到篮网队的处境,既然你没说,那就我来说吧。林书豪已经因腿筋受伤缺阵几周了。他们是唯一有摆烂权利但是不摆烂的球队!

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

榜单的前20名中,除了排名第四的复旦大学和第六名的北京大学这两所综合类高校之外,其余席位多被财经类和理工类高校占据。
然而,他认为,“在解释新兴市场危机的发生率时,美国的货币政策往往与新兴市场国内因素同样重要——如果不是更重要的话。”
《飞马》
Mark Williams, chief Asia economist at Capital Economics, adds: “We expect that the performance of EM exports will continue to improve in 2017, with export values rising modestly in year-on-year terms.”

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
From the themed collection: 五项注意理性选购“学区房”
Perspective

Trends and targets in antiviral phototherapy

In 2015, the number of migrant residents living in Shanghai dropped for the first time in the past 15 years, Shanghai Television reported Monday.
中国的商业银行是金融体系的控制中心,为实体经济提供的融资占总量的近70%。
Subdivided flats smaller than 100 square feet (9 square meters) can rent for $385 in the Asian city.
扎实推进新型城镇化。

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

On the US, Rabobank said it was cautious on the outlook following the election as president this month of Donald Trump.

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

"A 12-year-old boy doesn't want to start spending 100,000 euros."

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

汉娜库赫勒(Hannah Kuchler)是驻旧金山记者
自2014年10月以来,新兴市场出口额(以美元计算)一直下降,即使没有2008年至2009年全球金融危机期间的下降幅度极端,也比当时持续的时间要长得多,如第一张图表所示。

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

statement
节目28 歌曲《留声2012》①《滴答》(表演者:侃侃、李晨)②《我的歌声里》(表演者:曲婉婷、杜淳)

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

During a town hall hosted by MSNBC on last Monday night, host Rachel Maddow asked Clinton whether she would match a campaign promise Canadian Prime Minister Justin Trudeau made good on earlier this year.
1.It wasn’t me! – Because some things just aren’t worth taking credit for。

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

Sandy has caused large-scale damage, with more possibly to come.
He was under the impression people clicking on the adverts would earn him money. But instead he was charged every time someone clicked on the link.
4. Fruit Mold
蒋依依说,2013年人民币兑美元汇率上涨近3%,使北京成为了一个更加昂贵的旅游目的地。

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

10月中国出口同比下降6.9%,较上月3.7%的降幅有所恶化。疲弱的全球需求和中国成本上涨导致过去10年期间从中国大量流向世界的廉价商品减少。

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

不管你是想参加国际盛事、品尝美味佳肴、领略自然奇观、还是仅仅想在沙滩上放松身心,以下这些地方都值得一去。
A devastating financial crisis led business owners and corporate executives to be especially wary about adding staff or investing in new equipment. Some worry about risks from Washington or overseas. Others are seeing consumers maintain their slow-but-steady spending, providing little incentive to deploy their cash stockpiles.

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

而相对来说,普遍推出的新限购政策,并未让其他许多最近几个月表现突出的城市受到影响,房价同比依然大幅上涨。

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

Despite an abortive attempt in August to devalue the renminbi — a move that rocked global markets and was quickly abandoned by Beijing — China’s trade-weighted exchange rate was 8.5 per cent stronger in September than a year earlier, making Chinese exports less competitive.

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

Gisele, 37, came in second place, having earned $17.5 million, marking the first year she has not headed up the line-up since 2002.
调查显示,75%的顾客都知道可穿戴技术(无论是作为前卫的时尚潮流,还是新时代的技术工具),但是只有9%的顾客有兴趣使用它们。根据调查,仅有2%的人表示自己拥有可穿戴设备,其中大部分都是健身追踪器或智能手表。
我在世界最知名的公司之一找到了一份工作,对此学校的关系网络起到了重要的作用,鹿特丹管理学院(Rotterdam School of Management)一名毕业生表示,这家公司是学校的一个公司合作伙伴,因此我基本上是在我的邮箱收到工作申请书的。
Gary Oldman's first film as director in 20 years, and only his second ever, is a biopic of the pioneering 19th-century photographer Eadweard Muybridge, focusing on the affair between his wife, Flora, and Harry Larkyns, the theatre critic he kills. No casting confirmed, but Oldman had been chasing Ralph Fiennes and Benedict Cumberbatch. The man himself will play Muybridge's prosecutor.

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

'I look a lot like her, we're really like an old couple.'
昨日发布的新数据是对2015年全球贸易图景的第一张快照。但在这些数据发布之际,有越来越多的人担心2016年对全球经济而言将比此前预期的更为危机四伏。
智能冰箱
不过,10月份社会消费品零售总额增速放缓至10%,低于经济学家的预期。经济学家曾预期,10月份的增速将与9月份一致,同为10.7%。
Explaining the choice, the company cited “societal movements toward gender equality and fluidity, the consumer’s increased comfort with using color as a form of expression, a generation that has less concern about being typecast or judged and an open exchange of digital information that has opened our eyes to different approaches to color usage.”

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

在这份榜单上,名列C罗和梅西之后的是NBA球星勒布朗·詹姆斯(5300万英镑)和网球运动员罗杰·费德勒(4600万英镑)。
纽约前市长迈克尔·R·布隆伯格(Michael R. Bloomberg)正在为抗击气候变化花费自己私人财产的数千万美元,他在一份声明中说,“全球气温稳步上升、如今破纪录地上升的问题,不是一个未来的问题。这是一个迫在眉睫的明显危险,对经济、健康、环境和地缘政治有重大的危害。”

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

vt. 使成为可取,

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

Now that Chris and his girlfriend, Rose, have reached the meet-the-parents milestone of dating, she invites him for a weekend getaway upstate with Missy and Dean. At first, Chris reads the family's overly accommodating behavior as nervous attempts to deal with their daughter's interracial relationship, but as the weekend progresses, a series of increasingly disturbing discoveries lead him to a truth that he never could have imagined.

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

追踪制造业、服务业和建筑业商务活动的官方指标显示,10月份这几个驱动中国经济的关键行业的增长有所放缓。
In fact, one ancient saying was, "ifyou have Kucha, only one percent of the states in the Western Frontiers remain unsubmissive."
201312/270511.shtml重点单词
1985年2月是全球表面温度低于给定月份的20世纪平均值的最后一个月份,这意味着所有年龄在30岁以下的人都没有经历过低于平均温度的月份。最后一个低于20世纪平均温度的年度是1976年。

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

X
At that time, the chief executive was also under pressure, given Apple’s lack of clear product direction beyond milking the iPhone. Sensing blood, activist investors began to circle the company; first David Einhorn, then Carl Icahn, have lobbied for changes to how Apple is run and manages its finances. Mr Icahn has pushed for Apple to raise huge debt to return up to $150bn to shareholders and urged it to release more products, including a television set.
The new numbers, reported by a tracking initiative called the Global Carbon Project and published in the journal Nature Geoscience, came on the eve of a United Nations summit meeting meant to harness fresh political ambition in tackling climate change. Scientists said the figures showed that vastly greater efforts would be needed to get long-term global warming within tolerable limits.
“The employee said she was going out to buy boots, but was never seen again.”

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

4.Candice Swanepoel
Rank: 2

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

英国的一个收集全球气温纪录的科学小组也将在未来几周内提交报告。
在2017年FT对全球95个管理学硕士项目的排行中,虽然瑞士圣加仑大学(University of St Gallen)继续蝉联冠军,但法国和英国商学院分别以24个和18个项目入围成为中坚力量。超过一半的英国商学院排名上升,而只有一家法国商学院排名上升。三分之一的英国商学院排名上升5位,相比之下,三分之二的法国商学院排名下降5位或更多。
Lenovo CEO Yang Yuanqing
We'll start our review with the South American nations, and who else could we begin with, but the hosts Brazil. Rewind 18 months and they looked like they'd be struggling, but the appointment of 'Big Phil' Scolari has been inspired, and he's brought a belief to the team that was previously missing. Last years 3:0 demolition of Spain in the Confederations Cup final shocked many experts, and all of a sudden the Brazilians have expectations on them. Whilst you can't argue with that scoreline, we still wonder if Brazil have the firepower to win such a long tournament. Neymar is expected to conjure up the magic, but they're relying on Fred to come up with the goals. No disrepect to Fred, but the last two Brazilian teams to win the World Cup, in 2002 and 1994, could count on the likes of Ronaldo and Romario to lead the front line, two genuine legends of the game.
最佳乐队组合:Little Big Town

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

Klay Thompson added 19 points and Andrew Bogut scored 13 for the Warriors, off to the best start by an NBA team since Dallas won its first 14 games in 2002-03. Golden State needs three wins to equal the league record of 15-0, held by the 1948-49 Washington Capitols and 1993-94 Houston Rockets.
Many technicians think that during the course of this century computerized robots might compete and win against humans.
'But then it always challenges and nudges and says "well wait a minute".

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

'We are quite confident that it should sell towards the high end of the estimate or above.'
大型制药公司正在与美国癌症协会合作,以大幅折扣价为非洲患者提供抗癌药物。在整个非洲大陆,每年有45万人死于癌症,但其中有很多种癌症是可以治疗的,比如乳腺癌、宫颈癌和前列腺癌等。

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

北京市旅游发展委员会指出,污染问题是中国在吸引外国游客入境旅游的过程中面临的又一障碍。
即便这些改进最终会降低长期成本,遵守这条法律可能还是颇具挑战性。此外,2015年是各楼盘停用6号取暖油、改用污染更少的4号油的最后期限。
据外媒体育网站sbnation.com报道,德国战车在刚刚结束的比赛中以四粒进球完胜葡萄牙。比赛结果令人震惊,多数观察员原本希望葡萄牙的攻势能更猛烈些。但这是否是本届世界杯又一场比分悬殊的比赛?的确不足为奇。

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

Gitanjali won a $25,000 prize for scooping the top award.
然而据北京出入境边防检查总站(Beijing General Station of Exit and Entry Frontier Inspection)称,只有14,000名旅客办理了过境免签手续,远低于官方此前预计的20,000人。
“能够有这些天赋异禀的艺术家为电影的音乐进行神助攻,我们非常能高兴。”这场秀的制作人Michael De Luca 和Jennifer Todd周五发表申明时如是说。“能邀请到他们登上第90届奥斯卡也是一种荣幸。”

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

The 2017 grads of Tsinghua University earn an average salary of 9,065 yuan per month, according to the survey released by xinchou.cn, an internet salary survey and report provider.

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

雇主因种族、肤色、性别、国籍、宗教、年龄或残疾而歧视员工属于违法行为。但美国多数州至今依然不保护LGBT群体的工作权益。苹果公司CEO蒂姆库克希望消除这种差异。11月份,库克在《华尔街日报》(Wall Street Journal )评论版对页发表了题为《平等就业对企业有益》(Workplace Equality Is Good for Business)的文章,敦促联邦立法,以免就业者因性取向而受到歧视。

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

中国的旅游业官员正力图在2014年扭转入境游客减少的情况,专家认为,如果能对其过时的旅行团进行改进并降低票价,这一计划就有可能实现。
伊丽莎白?泰勒和理查德?伯顿的爱情之

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

估计当高盛公布自己2009年的奖金规模时,美国国会和媒体又会气得抓狂。但这些怨气终将只是过眼云烟,改变不了什么。所谓“高盛招人恨”的故事实在是拖得太长了。
But despite the anticipation, it seems the underwear brand's debut in the Chinese city is not going entirely to plan.
他表示:“消费者将需要更多时间回归,这就是为什么我们聚焦于一项我们知道会奏效的方案,专注于价格可承受能力和城市地区的高端(饮料)。”他补充称,他相信,该公司将继续在中国扩大市场份额,同时正为消费者支出再次提速做好准备。
4. New reserves of helium discovered

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

“白”之禁忌
《倒霉蛋:罗伯特·博斯特的生与死》(Jinx: The Life and Deaths of Robert Durst),HBO,2月8日播出。《追捕弗雷德曼家族》(Capturing the Friedmans)的导演安德鲁·杰瑞克奇(Andrew Jarecki)执导了这部六集系列纪录片,在片中与博斯特先生通力合作。博斯特出身纽约房地产世家,与数起谋杀事件有关,他的第一任妻子失踪之谜至今未曾解开。

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

像中国人口这么多的国家,关于寂寞的病毒式模仿会这么流行实在是件很讽刺的事情。这句看上去很无厘头的话被用在了所有可能搭配的排列中,用在了所有场合,比如,“哥看的不是书,是寂寞。”
Global pharmaceutical spending will surpassthe trillion dollar threshold in 2014, with high prices for innovativehepatitis C and cancer drugs in the US, a new study says. By 2018spending is expected to increase by another 30 percent.

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
From the themed collection: 菏泽“取消限售”影响有多大
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

Spending on medicines in "pharmergingmarkets" will rise more than 50 percent over the next five years, ThePharma Letter said, citing IMS.

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

GDP reached 74.4 trillion yuan, representing 6.7-percent growth.
No. Football punditry is a mug’s game. Better to have the benefit of hindsight. There have been 20 previous World Cups. Of those, Brazil (five titles) and Germany (four), are regular contenders. Home advantage helps, with host nations winning the trophy six times. But next year’s festival of football is being held in Russia, which has the lowest-ranked team in the tournament.
With a bit of help from Charles Dickens, let’s take a look back at the year in which almost nothing worked:
Any decision by China’s policymakers to begin selling down the country’s huge reserves would have a large impact on markets.

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

巴蒂说道:“纵观亚洲高校前三百名榜单,我们可以看到,现如今,动态、多样化且颇具竞争力的高等教育园区正在亚洲地区逐渐形成,中国则是这个发展过程中极其重要的一部分。”
对于该行业规模有多大,众说纷纭,但高盛(Goldman Sachs)的数据表明,在2012至2014年期间,该行业的贷款规模从60亿元人民币增长至830亿元。

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

"They are fairies. Can’t they do something else except falling in love?" another Douban user Amy said.
Its selection of Mr Trump neither accords with the votes cast in the election nor reflects judgment of the candidate’s merits, as desired by Alexander Hamilton.
The letter mysteriously arrived at the California University of Pennsylvania, in the north-eastern state of Pennsylvania, 10 days ago. Written to Mr Moore, the two-page letter was postmarked 20 February 1958 and signed "love forever Vonnie".

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

Concerns about China’s economy have recently dragged down global financial markets, affecting prospects for the eurozone and many others. Such worries are one reason why the European Central Bank is expected on Thursday to unleash a new round of economic stimulus.
The raised decoration shows a cartouche — an oval frame around Egyptian hieroglyphics indicating a royal name. Above the frame archaeologists could make out the symbol of an eye and that of a cobra.
While falling prices for oil and other inputs have supported profit margins, the positive impact has been outweighed by falling prices for finished goods, He Ping, a statistician at the bureau’s industrial department, said in a statement accompanying the data.

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

Video editors likely benefited from the same factors that caused the increase in photography jobs. It stands to reason that this kind of work expands alongside the need for increasingly sophisticated and appealing website designs.
办事处副局长卢华东说:“自治区已投资40亿元人民币(约合6亿美元),用于推动贫困地区特色的产业,去年重新安置了77000名贫困人口。”

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
From the themed collection: 棚改贷款审批权限未上收总行
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

Thor: Ragnarok was so much funnier than you could ever expect it to be, and it's all thanks to the genius of Jeff Goldbloom combined with the genius of Taika Waititi—the latter of whom both directed the movie AND played a extremely earnest dude made out of rocks.
4) I often feel inhibited in social interactions 0 1 2 3 4
1999年中国航空工业第一、第二集团公司(之后两者合并为中国航空工业集团公司)的成立标志着中国开始进军商业航天领域,显示了中国迈向这一行业的绝心与意志。但实现这一雄心的脚步并不那么平坦。20年之后毫无疑问中国已经成为了大型商用航天领域的成熟玩家,将其他几国远远甩在身后,并有望打破空客和波音的长期垄断。

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

互联网已经让世界变成了平面,Facebook让我们大家团结起来,组成一个大家庭。我们的祖父那一辈人是地区的传承者,我们这代人是国家的传承者,而你们则是世界的传承者。你现在和任何人的联系只有4.74个人的距离,到达全球任何有人居住的角落平均只需要两天时间。你可以踏上旅途。无论是非洲、欧洲、印度、中国还是巴西,前往那些能让你学到最多东西的地方,拥抱那个可以教给你最多东西的国度。
其中,由于IT/互联网/通讯/电子行业迅猛发展,吸纳了近三成的2016年应届毕业生。

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

['steibl]
我们对已经达成或者希望达成的一些区域贸易安排一直持开放态度,也乐见其成。只要是有利于贸易自由化的,我们都会去参与、去推进。
不过,我们大部分人都有自知之明,在粉饰过去的同时就已意识到自己是在自欺欺人。我们知道这种倾向在政治界的危害(看看布什和克林顿吧)。可是,在时尚界又何尝不是如此呢?

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

The only things in the way are his staff, Republicans in Congress and the limits of his power. And those are important. Campaign promises of 45 per cent tariffs on Chinese goods have turned into investigations into Beijing’s intellectual property regime.

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
From the themed collection: 2014红棉奖建材产品成最大赢家
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

charitable
[in'vig?reit]

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
From the themed collection: 业务下滑 二手经纪人转战售楼处
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

“A worker sent a text to a colleague saying he was quitting and asked her to forward it to management.”
流行天后嘎嘎小姐凭借她在HBO热门短剧《美国恐怖故事:旅馆》中扮演的反面角色获得了最佳女主角的奖杯。当她上台领奖时,她的情绪很激动。

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

以下将007系列电影官方主题曲按受欢迎程度由低到高进行排序。其中还荣誉推荐了两首有可能不属于官方歌曲的曲子。它们一样很好听。
西门子(Siemens)去年破纪录了,通过将医疗部更名为Healthineers一举斩获两项大奖。该公司不仅因为将两个单词生拼硬造出另一个无比蹩脚的新词从而荣获“马丁?卢克斯奖”(Martin Lukes prize),同时还凭借现场视频中一位倾情演唱的CEO和身着氨纶紧身衣卖力献舞的员工们,摘得史上最尴尬企业歌曲的金牌。

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

你如何知道你需要喝水了?这有一系列的诱因:嘴唇发干、头晕、头痛、尿量低和口渴。然而,这种智能瓶能在你的身体意识到缺水前就提醒你。
He was under the impression people clicking on the adverts would earn him money. But instead he was charged every time someone clicked on the link.

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
From the themed collection: 海淀最大规模共有产权房启动申购
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

Hugo Boss, Chevrolet and Kleenex dropped off the list, the report said.

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

A spokeswoman for Harvard University declined to comment on the report. "We do not comment publicly on the admissions status of individual applicants," Rachael Dane wrote in an email.
智能皮带
But Michael DeFranco, chair of Baker & McKenzie’s M&A practice, hailed the Chinese group’s investment in developed economies.
Volatility in currency markets is also likely to be a factor for agricultural commodity prices in the next 12 months, with the euro likely to depreciate as a result of French, Dutch and German elections, Rabobank reckons.

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
From the themed collection: 北京通州启动群租房专项治理
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

1月份中国居民消费价格指数(CPI)出现上涨,在本月金融市场动荡为主的背景下,该消息对于这个世界第二大经济体来说是个令人鼓舞的迹象。

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

在这部暂未定名的电影里面,两段交错的三角恋,偏执,背叛等元素与音乐场面相互映衬。参演此片的有克里斯蒂安·贝尔(ChristianBale)、凯特·布兰切特(Cate Blanchett)、迈克尔·法斯宾德(Michael Fassbender)、瑞恩·高斯林(RyanGosling)、鲁妮·玛拉(Rooney Mara)以及娜塔丽·波特曼(Natalie Portman.)。
Taiwan Semiconductor Manufacturing Company (TSMC).” Previous reports have pegged the screen size at just under the 5 inches of Samsung’s Galaxy 4.
脱发和头发变白的原因是相关的,科学家首次确认了对此负有责任的细胞。

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

报告指出,大连万达集团主席王健林以321亿美元的个人财富荣登榜首,而马云的个人财富在2015年上涨了41%。
质量强国、制造强国

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

这是英国《金融时报》第16份全球EMBA排行榜。
赫洛维兹对爱尔兰广播公司RTE表示,他的新邦德形象强烈忠于50年代的邦德。

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

'It is most probably from a mine in South Africa known as Premier mine and now as Cullinan, where most of the blue diamonds are from. Probably in the last 30 years,' Mr Lunel said.

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
From the themed collection: 京津冀建材向绿色功能转变提速
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

May everything beautiful and best be condensed into this card. I sincerely wish you happiness, cheerfulness and success.
These concerns are real, but there are ways around them. For example, you can use your survival job to show employers that you're willing to work hard. And you can continue your job search after work.
7. 艾米-亚当斯 1350万美元

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

Happy new year, my best friend.祝我的挚友新年快乐。
出境旅游超过1.2亿人次;
Domestic action movie "Wolf Warrior II" was top on the list and became the country's highest-grossing film ever, raking in 5.68 billion yuan in ticket sales.
Las Vegas Shooting

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

The women in tech: Tech takes a second turn as a category on the Power Women list. Five tech women made the top 25 this year, including Facebook’s Sheryl Sandberg (No. 6), Rometty (No. 12) and HP’s Meg Whitman (No. 15). There are 16 tech women in total, including also Susan Wojcicki, SVP of ads at Google (No. 30) and Sun Yafang, chair of Huawei Technologies (No. 77).
这位官员表示,相比其他职位来说,那些对教育背景或工作经历没有特殊要求的职位更受欢迎,近些年报名人数达到数千人的基本上都是这种职位。

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

The End of the Road
这一问题也打击了中国在WTO框架内获得市场经济地位的努力。中国声称,在其加入WTO满15周年的今年12月,应当自动获得市场经济地位。如果中国获得了该地位,那么这可能影响美国等国对中国发起反倾销案的能力,因为这将使他们不能用替代国的价格进行比价。
发展最迅速的初创公司往往具有全球化的视野。未来一年,美国总统特朗普已经实施的移民限制,以及英国作为退欧的一部分而在考虑的限制措施,可能会对企业招聘形成障碍。

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
From the themed collection: 抗菌建材市场巨大 标准亟待完善
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随着中国经济结构的演变,富豪榜单也在发生改变。
Kobe Bryant really hasn't changed that much since high school, even though it's been 16 years since he's walked the halls of Lower Merion High School.

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